Monday, June 16, 2014

The Neuroscience of the Future


Neural prosthetics, brain-computer interfaces (BCI), “closed-loop” deep brain stimulation (DBS) devices, and a world without human brain disorders. The first three of these are already here... is the last one possible?

In the utopian world of The Hedonistic Imperative, an ambitious, admirable (and unlikely) 1995 manifesto by philosopher David Pearce, the goal is to “eradicate suffering in all sentient life” through paradise engineering —  which involves sophisticated applications of nanotechnology, genetic engineering, and psychopharmacology. And going beyond the eradication of suffering, “Life-long happiness of an intensity now physiologically unimaginable can become the heritable norm of mental health.” 1

Lest you think such speculation is limited to those wacky transhumanists, respected neuroscientists Kent Berridge and Morten Kringelbach have written seven reviews on the neuroscience of happiness and pleasure and well-being. In contrast to the vegan and animal rights supporter Pearce, however, Berridge & Kringelbach (e.g., 2012) see animal research as the key to unlocking the brain mechanisms of human pleasures.

Sure, we have BRAIN 2025 and the DARPA deep brain stimulation awards. But we're getting ahead ourselves here, aren't we? Using neuroscience to alleviate human suffering takes precedence over the attainment of  “a sublime and all-pervasive happiness” in wealthy Western post-industrial societies (doesn't it)? Doesn't it??


Neurofutures that aren't mine

There used to be a blog called Neurofuture (“Brain Science and Neofuturism”), written by . It covered topics like HedWeb and neuroscience nanotechnology and NeuroArm and the Blue Brain Project back in 2006-2007.

Since February 2012, there's been an unrelated NeuroFuture twitter feed @NeuroFutureNews (“Mind-blowing tweets! Follow me if you are interested in brain, bionics, BCI, robotics and mind-controlled news”). A guy named wolfgang berke has had the @neurofuture account since March 2010, but he hasn't tweeted once.


And now, there's NeuroFutures 2014, a conference in Seattle starting tomorrow:

NeuroFutures Conference: June 17 - 18, 2014

Thought leaders in research, engineering, industry, and clinical domains will explore how the intersection of neurotechnology innovations in neuromodulation, brain mapping, neuroimaging, big data analytics, and brain computer interfaces will transform our understanding of neural systems and enable life-changing medical treatments.

If you're already in Seattle, you can attend a public lecture by a prominent DBS neurosurgeon today at 7 PM:

NeuroFutures Public Lecture: 7:00 PM, June 16

Dr. Andres Lozano from the University of Toronto will kick off the NeuroFutures summit with a talk on “The Future of Brain Stimulation: Parkinson’s, Depression, Alzheimer’s and beyond" (see his related TED Talk here). Afterwards, he will discuss his work with science educator and author David Heil, and field questions from the audience.

Organizational and industry sponsors include Center for Sensorimotor Neural Engineering, Allen Institute for Brain Science, Cyberonics, and Neurotech Business Report,3 among others.

Why NeuroFutures?

Problem: One in four U.S. adults suffer from a diagnosable neurological disorder and a quarter of these are seriously disabled as a result. These patients endure immense physical and emotional suffering, and their family members and caregivers bear a heavy emotional and financial burden. From a scientific standpoint, the human brain is the most sophisticated computing system in the known universe, and we are only starting to understand how it works.
. . .

Plan: To accelerate the pace and impact of innovation we will bring together neurotechnology thought leaders from different disciplines to exchange ideas and forge collaborations at the two-day NeuroFutures Conference on June 17 and 18, 2014 in Seattle, Washington. We will highlight people and resources in the Northwest that position the region to play a leading role in our NeuroFuture...


So what will it be... better living through chemistry (pharmaceuticals), biotechnology, or engineering? With conference sessions on BCI and Neuromodulation Innovations, Learning, Plasticity, and Adaptation in Neural Interfaces, and The Past, Present, and Future of Closed-loop Neuromodulation, one might think it's a great time to be a Neuroengineer at places like the Center for Sensorimotor Neural Engineering, the Brain-Machine Interface Systems Laboratory, and the Neural Prosthetic Systems Laboratory.


Footnotes

1 The HedWeb manifesto has been online in its entirety since 1995, I believe. For many years, the labyrinth of links and early-acquisition domain names such as biopsychiatry.com, huxley.net, mdma.net, opioids.com, cannabis.net, and general-anaesthesia.com were entirely unattributed, except for affiliation with an organization known as BLTC RESEARCH. But be careful, or you could fall down the rabbit hole of supercentenarian.com or reproductive-revolution.com or oxytocin.org or sensualism.com or nootropics.com or.....2

2 OMFG! There are 2,244 PARADISE-ENGINEERING BLTC WEBSITES as of JUNE 2014:
Paradise-engineering websites (2014)
Good domains for a better world?

3 Neurotech Business Report was the first to break the news about the failed BROADEN clinical trial for treatment-resistant depression, and they've continued their close coverage of the neuromodulation market.


top image via Alternative Media News



Figure 1. Pleasure Cycles (Berridge & Kringelbach, 2012), from Building a neuroscience of pleasure and well-being.

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3 Comments:

At June 16, 2014 4:04 PM, Anonymous Anonymous said...

The sloth bear is the only species of bear found in South India.
The old man went on to explain to the boy that the three men who seemed
to be in a heated discussion weren't really arguing. He quickly rushed back to his apartment along Nimitz Boulevard and up the stairs to his door.

 
At June 17, 2014 12:37 AM, Blogger Robert Moss said...

You might be interested in a new theoretical article which suggests Alzheimer's, autism, and schizophrenia are disorders of disrupted cortical columns at http://aimspress.com/aimsn/ch/index.aspx

 
At June 17, 2014 1:14 AM, Blogger The Neurocritic said...

Wait a minute! There's been an inversion in the world of spam commenting!

First we have a completely anonymous comment stringing together three random sentences -- with no spam advertisement for things like work from home, acne remedies, permanent lip augmentation gurgaon, or barber supply company (actual spam I've received in the last 24 hrs). The three sentences are selections from Yahoo! Voices that I found via Google: #1 (sloth bear), #2 (heated discussion), #3 (Nimitz Boulevard).

Next we have a seemingly real comment on a potential topic of interest, but the link is not to a real article, but to an entire journal, which has recently dropped its inaugural issue. The comment was from the Editor, who has been using his new scientifically respectable position to inappropriately promote his private clinic: “Dr. Robert A. Moss becomes the AIMS Neuroscience founding Editor-in-Chief“ Announced by the Center for Emotional Restructuring LLC. AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers in the field of neuroscience. The journal aspires to provide a forum to move theoretical neuroscience forward in a more effective manner.

This advertorial appeared on PRWeb, but I'm not going to link to it. I would think such an ad would present a conflict of interest -- the use of a supposedly impartial position as journal editor to promote one's business.

 

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