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Copyright © 2007 Cell Press. All rights reserved.
Cell, Vol 131, 391-404, 19 October 2007
Article
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward RegionsVaishnav Krishnan et al.SummaryWhile stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The molecular mechanisms underlying such resilience are poorly understood. Here, we demonstrate that an inbred population of mice subjected to social defeat can be separated into susceptible and unsusceptible subpopulations that differ along several behavioral and physiological domains. By a combination of molecular and electrophysiological techniques, we identify signature adaptations within the mesolimbic dopamine circuit that are uniquely associated with vulnerability or insusceptibility. We show that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior. Our results validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance, and illustrate the importance of plasticity within the brain's reward circuits in actively maintaining an emotional homeostasis.
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posted by The Neurocritic @ 10:45 AM
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2 Comments:
But speaking about the article for a moment...I can't decide whether this article is really any good or not. They split their wimpy rodent population into two groups despite the fact that their underlying index looks pretty continuous, and then use a very different strain as a "control" group. That said, it would look like there is an actual phenomenon of interest going on here, and this seems to make at least some progress towards figuring out what.
Awesome links. Actually, due to problems like these, the Google ads have been taken off the Cell Press websites.
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