tag:blogger.com,1999:blog-21605329.post2530418827378920437..comments2024-03-22T00:30:09.536-07:00Comments on The Neurocritic: Good News/Bad News Update on Nucleus Accumbens DBS for Treatment-Resistant DepressionThe Neurocritichttp://www.blogger.com/profile/08010555869208208621noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-21605329.post-72251357407963087542009-12-30T19:57:54.581-08:002009-12-30T19:57:54.581-08:00Here again, this time not quite so late to the par...Here again, this time not quite so late to the party... I am a current patient in the Reclaim Study at UPenn, where the DBS targets the VC/VS, not the nucleus accumens (not that I have a fraking clue what the difference is -- I am a severely depressed person, not a neuroscientist). Anyway, the study is/was, for a long 16 weeks, double-blind and placebo-controlled (or rather "control-group"-controlled -- they had implants but they were all set to zero). As I said in my other comment, there have been good times and bad times, but they've finally found a setting that at least leaves days feeling more like extra-long days rather than months or even years, and I have even laughed a couple of times in the last two weeks (don't remember when I last did that). So try and take it from me, really, and I'll hurt you, even if I am nowhere near remission. And I don't care right now about the longer-term effectiveness either. If it stops working, I'll eventually kill myself. But for now, I only wish to die every OTHER day!!!deselbyhttps://www.blogger.com/profile/02332086891369072211noreply@blogger.comtag:blogger.com,1999:blog-21605329.post-59150142154639892682009-11-28T04:17:52.344-08:002009-11-28T04:17:52.344-08:00An interesting study, but I wish they'd have m...An interesting study, but I wish they'd have made it placebo-controlled - it's so easy with DBS, you just turn off the stimulator. There are "ethical issues", but I think the biggest ethical issue is that DBS is being used in extremely ill people with very little placebo-controlled evidence...Neuroskeptichttps://www.blogger.com/profile/06647064768789308157noreply@blogger.comtag:blogger.com,1999:blog-21605329.post-59754373903019553662009-11-26T09:50:35.083-08:002009-11-26T09:50:35.083-08:00Thank you for posting the complete reference list....Thank you for posting the complete reference list. The shortening was an inadvertent result of the researchblogging.org software that creates code to track references so they appear on their website.The Neurocritichttps://www.blogger.com/profile/08010555869208208621noreply@blogger.comtag:blogger.com,1999:blog-21605329.post-39583885040223817202009-11-26T04:10:57.206-08:002009-11-26T04:10:57.206-08:00The list of co-authors is incompletely cited: Bett...The list of co-authors is incompletely cited: Bettina H. Bewernick, René Hurlemann, Andreas Matusch, Sarah Kayser, Christiane Grubert, Barbara Hadrysiewicz, Nikolai Axmacher, Matthias Lemke, Deirdre Cooper-Mahkorn, Michael X. Cohen, Holger Brockmann, Doris Lenartz, Volker Sturm and Thomas E. Schlaepfer. Volker Sturm is the neurosurgeon and Thomas Schlaepfer heads the psychiatric neurosurgery work group.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-21605329.post-24519101954166990892009-11-22T15:29:56.134-08:002009-11-22T15:29:56.134-08:00I wonder about the longer-term effectiveness of th...I wonder about the longer-term effectiveness of this treatment. For instance, does the rest of the brain react by eventually undoing the effects of the stimulation?Anonymousnoreply@blogger.com